北京索莱宝科技有限公司  张净花  13426459985  010-56371206

产品编号：a16927R

英文名称：NIT1

中文名称：

别    名：NIT1; NIT1_HUMAN; Nitrilase 1; Nitrilase homolog 1.

研究领域：肿瘤  细胞生物  染色质和核信号  神经生物学  信号转导  细胞凋亡

抗体来源：Rabbit

克隆类型：Polyclonal

交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit, 

产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500  （石蜡切片需要做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量：36kDa

细胞定位：细胞浆 

性    状：Lyophilized or Liquid

浓    度:1mg/1ml

免 疫 原:KLH conjugated synthetic peptide derived from human NBL1

亚    型:IgG

纯化方法:affinity purified by Protein A

储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

生 产 商：Solarbio

产品介绍：

background:
Play a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. it is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2.

Function:
Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity).

Subcellular Location:
Cytoplasm. Mitochondrion.

Tissue Specificity:
Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Post-translational modifications:


Similarity:
Belongs to the UPF0012 family.
Contains 1 CN hydrolase domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.